Key result
Increasing vascular transmural pressure reduces vascular resistance less in the leg compared to the hand.
Why the study?
Does an increase in vascular transmural pressure affect blood flow differently in the hand versus the leg in papaverine-relaxed subcutaneous vascular beds?
Population
6 healthy humans
Comparison
Increase in vascular transmural pressure induced… vs Comparison of response between the dorsum of the…
Design
Other
Authors
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Hypothesis-generating for limb-specific resistance vessel distensibility; prospective studies needed before clinical translation.
Does an increase in vascular transmural pressure affect blood flow differently in the hand versus the leg in papaverine-relaxed subcutaneous vascular beds?
The distensibility of resistance vessels is smaller in the leg than in the hand, likely due to structural adaptation to increased hydrostatic pressure.
Henriksen et al. (1979) studied Healthy (n=6). Increase in vascular transmural pressure (lowering area below heart level) vs. Hand vs. leg was evaluated on Blood flow and vascular resistance. Increasing vascular transmural pressure by lowering the area below heart level caused a smaller relative decrease in vascular resistance in the leg compared to the hand.