Key result
Stent geometry alters pressure-flow phase shifts and inter-strut wall shear stress in computational coronary models.
Why the study?
Does stent geometry affect the phase shift between pressure and flow waveforms and wall shear stress in stented human coronary arteries?
Does stent geometry affect the phase shift between pressure and flow waveforms and wall shear stress in stented human coronary arteries?
Computational fluid dynamics modeling demonstrates that coronary stent geometry significantly alters local hemodynamics, including phase shifts and wall shear stress, which may influence restenosis risk.
Answers are grounded in this paper and cite their sources.
Stent geometry may influence restenosis risk via hemodynamics; leaves open clinical relevance and need for in vivo validation.
Shear stress is known to play a central role in restenosis formation and is sensitive to stent geometry. Alterations of the phase shift between pressure and flow waveform created by a different stents were studied to compare the hemodynamic effects of stent design properties on restenosis in stented human coronary artery. Blood pressure waveforms were computed in three different sites, pre-stent, middle of stented arterial segment, and post-stent regions using computational fluid dynamics. Blood flow was assumed as pulsatile, incompressible, and Newtonian flow. Rigid boundary conditions were assumed for all models. The governing Navier-Stokes equations were solved using commercial software package (Fluent V6.0.12). Stents were assumed with real structure and modeled using the commercial software package (Gambit, V2.0). The alterations of the phase shift between pressure and flow waveform created by a different stents were investigated in three major regions using commercial software package (Matlab, V7.0). It is concluded that stent geometry changes the phase shift between pressure and flow waveforms in stented human coronary artery, and wall shear stress between stent struts was sensitive to these variations. The results show that variation in the phase shift is sensitive to stent geometry.
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Dehlaghi et al. (2008) studied Restenosis in stented human coronary artery. Stent geometry vs. Different stent designs was evaluated on Phase shift between pressure and flow waveform and wall shear stress. Stent geometry altered the phase shift between pressure and flow waveforms in computational models of stented human coronary arteries, affecting wall shear stress between stent struts.
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