Key result
Echocardiographic measures of left ventricular function were frequently unobtainable in patients with Duchenne muscular dystrophy and demonstrated limited correlation with cardiac MRI.
Why the study?
Does echocardiography accurately assess left ventricular function compared to cardiac MRI in patients with Duchenne muscular dystrophy?
Cross-Sectional (n=12)
Single-blind
No
Does echocardiography accurately assess left ventricular function compared to cardiac MRI in patients with Duchenne muscular dystrophy?
Effect estimate: r = 0.59
p-value: p=0.042
Echocardiography correlates poorly with cardiac MRI for assessing left ventricular function in Duchenne muscular dystrophy, suggesting CMR should be considered early for accurate annual assessment.
Echocardiography may yield unreliable LV function data in DMD; leaves open whether CMR should replace annual screening.
Background Duchenne muscular dystrophy (DMD) causes skeletal muscle weakness and cardiomyopathy (CM). Current recommendations are for annual left ventricular (LV) function assessment after age 10 years. Although echocardiographic image quality in DMD patients can be affected by scoliosis and adipose tissue, recent reviews recommend echocardiography as the standard imaging modality. We hypothesized that objective and subjective LV functional assessment by echocardiography in DMD is suboptimal compared to cardiac MRI (CMR).
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Soslow et al. (2014) conducted a cross-sectional in Duchenne muscular dystrophy (n=12). Echocardiography vs. Cardiac MRI was evaluated on Correlation between M-mode fractional shortening (MMFS) by echocardiography and LVEF by CMR (r = 0.59, p=0.042). Echocardiographic measures of left ventricular function were frequently unobtainable in patients with Duchenne muscular dystrophy and demonstrated limited correlation with cardiac MRI.
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