Key result
The rpsO mRNA pseudoknot is required for S15 recognition and translational control via competitive binding.
Population
E. coli ribosomal protein S15 and its mRNA (in vitro and in vivo models)
Design
Preclinical
Authors
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Clarifies prokaryotic translational control; leaves open relevance to cardiovascular gene regulation.
The pseudoknot structure in rpsO mRNA is essential for S15 recognition and translational control in E. coli.
Philippe et al. (1994) studied this question. Mutations in the translational operator of rpsO mRNA was evaluated on Binding of protein S15, formation of the 30S/mRNA/tRNA(fMet) ternary initiation complex, and S15 inhibition ability. The pseudoknot structure in rpsO mRNA is required for S15 recognition and translational control, with mRNA and 16S rRNA efficiently competing for S15 binding.
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