Key result
PMA accelerates and augments rat aortic smooth muscle contraction via TxA2/PGH2 receptor-mediated prostaglandin release.
Population
Deendothelialized rat aorta
Comparison
Phorbol 12-myristate 13-acetate combined with… vs PMA alone
Design
Preclinical
Authors
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No direct clinical implications from rat aorta; leaves open TxA2/PGH2 mediation in human vascular responses.
In rat aorta, phorbol ester-induced contraction is augmented by endogenously released prostaglandins acting primarily via the TxA2/PGH2 receptor.
Williams et al. (1994) studied this question. Phorbol 12-myristate 13-acetate (PMA) was evaluated on Smooth muscle contraction. Phorbol 12-myristate 13-acetate induces the release of prostaglandins in rat aorta that accelerate and augment smooth muscle contraction, largely mediated through TxA2/PGH2 receptor activation.
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