Population
Aorta from 7- to 12-month-old and 4- to 6-week-old spontaneously hypertensive rats and Wistar-Kyoto rats
Design
Preclinical
Authors
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PGI2 may mediate endothelium-dependent contraction in rat aorta; leaves open relevance to human hypertension.
In hypertensive and normotensive rat models, PGI2 released in response to acetylcholine may serve as the endothelium-derived contracting factor mediating aortic contraction.
Rapoport et al. (1996) studied this question.
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