Key result
Higher FMD linked to better executive function in sedentary, middle-aged adults with hypertension and obesity.
Why the study?
Is impaired vascular health associated with reduced neurocognitive performance in overweight adults with high blood pressure?
Cross-Sectional (n=124)
Is impaired vascular health associated with reduced neurocognitive performance in overweight adults with high blood pressure?
Impaired flow-mediated dilation is associated with worse executive function in overweight, middle-aged adults with high blood pressure.
Impaired FMD was associated with worse executive function; leaves open whether vascular interventions affect cognition in this group.
The relationship between vascular health--including flow-mediated dilation (FMD) and intima medial thickness (IMT)--and neurocognitive performance was examined in a sample of 124 sedentary, middle-aged adults with high blood pressure (systolic blood pressure, SBP, 130-159 mmHg or diastolic blood pressure, DBP, 85-99 mmHg) who were overweight or obese (body mass index 25.0-39.99 kg/m²). Patients completed a neuropsychological test battery, including measures of executive function and psychomotor speed, and measures of IMT and FMD were obtained. Hierarchical multiple regression analyses were used to investigate the association between vascular measures and neurocognitive performance after controlling for demographic factors and cerebrovascular risk factors. Higher levels of FMD predicted better executive function (b = 0.90, p = .045). Greater IMT tended to be associated with slower psychomotor speed (b = -0.82, p = .084), with the effect attenuated after controlling for FMD. Impaired FMD is associated with worse neurocognitive functioning among overweight adults with high blood pressure.
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Smith et al. (2011) conducted a cross-sectional in High blood pressure and overweight/obesity (n=124). Vascular health (flow-mediated dilation and intima medial thickness) was evaluated on Executive function (b = 0.90, p=0.045). Higher levels of flow-mediated dilation predicted better executive function (b = 0.90, p = 0.045) in sedentary, middle-aged adults with high blood pressure and overweight or obesity.
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