Key result
New data pooling standardization reveals a nonlinear hypercapnic ventilation-CO2 output relationship with downward concavity.
Population
8 healthy subjects (from reported hypercapnic exercise-response data)
Comparison
New method of pooling multiple subject data for… vs Conventional approaches using pooled subject data
Authors
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A new standardization procedure for pooling subject data allows for sensitive detection of occult nonlinearities in physiological relationships, overcoming limitations of conventional pooling methods.
A new standardization procedure for pooling subject data allows for sensitive detection of occult nonlinearities in physiological relationships, overcoming limitations of conventional pooling methods.
Chi‐Sang Poon (1988) studied Healthy (n=8). Standardization procedure for individual response curves was evaluated on Linearity of hypercapnic ventilation-CO2 output and ventilation-tidal volume relationships. A new standardization procedure for pooling subject data revealed that the hypercapnic ventilation-CO2 output relationship is nonlinear with a downward concavity in 8 healthy subjects.
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