Key result
The intrinsic mode function method demonstrated that most parameters of the indicial functions for pulmonary blood pressure vary linearly with the degree of hypoxia, while a few vary quadratically.
The study proposes a novel mathematical method to quantify the nonlinear relationship between complex nonstationary biological signals, such as pulmonary blood pressure and hypoxia.
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May refine hypoxic pulmonary pressure modeling; leaves open clinical validation before physiological application.
Huang et al. (1999) studied Pulmonary hypertension (n=16). Step hypoxia vs. Normal sea-level air (20.9% O2) was evaluated on Nonlinear indicial response of pulmonary blood pressure to step hypoxia. The intrinsic mode function method demonstrated that most parameters of the indicial functions for pulmonary blood pressure vary linearly with the degree of hypoxia, while a few vary quadratically.
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