Key result
The intrinsic mode method successfully resolved nonstationary pulmonary blood pressure signals into oscillatory intrinsic mode functions and mean trends, enabling the derivation of analytic indicial response functions to step hypoxia.
Presents a novel mathematical method using intrinsic mode functions to analyze nonstationary biological variables, such as pulmonary blood pressure responses to hypoxia.
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May advance analysis of dynamic hemodynamics in animal models; leaves open human validation and clinical translation.
Huang et al. (1998) studied Pulmonary hypoxic hypertension (animal model). Step hypoxia vs. 20.9% oxygen (normal air) was evaluated on Indicial response of pulmonary blood pressure to step hypoxia. The intrinsic mode method successfully resolved nonstationary pulmonary blood pressure signals into oscillatory intrinsic mode functions and mean trends, enabling the derivation of analytic indicial response functions to step hypoxia.
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