Key result
Head-up tilt testing induces syncope in LQTS preceded by a ~36% drop in RR intervals.
Why the study?
Does head-up tilt table testing induce neurally mediated syncope in patients with long QT syndrome and a history of syncope?
Population
6 patients with long QT syndrome (LQTS) and a history of syncope
Design
Case_series
Authors
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May indicate neurally mediated syncope susceptibility in long QT syndrome; hypothesis-generating case data leave association open for validation.
Observational (n=6)
Does head-up tilt table testing induce neurally mediated syncope in patients with long QT syndrome and a history of syncope?
p-value: p=0.003
Patients with long QT syndrome and a history of syncope may be susceptible to neurally mediated (neurocardiogenic) syncope, which should be considered as a diagnostic alternative to torsades de pointes.
Antonio G. Hermosillo (1999) conducted an observational in Long QT syndrome (n=6). Head-up tilt table testing (70 degrees) was evaluated on RR interval changes 2 min before the onset of syncope (p=0.003). Head-up tilt table testing induced syncope in all 6 patients with long QT syndrome, with RR intervals significantly decreasing 2 minutes before syncope onset (980 vs 630 ms, P=0.003).
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