September 26, 2008Blood Coagulation & Fibrinolysis
Risk factors for venous thromboembolism in the elderly: results of the master registry
Key result
Age >75 in VTE is linked to ~146% higher immobilization and severe medical disorders.
- OR 2.46
- 95% CI 1.85-3.27
- n=2,119
Why the study?
Do the major risk factors for venous thromboembolism differ between elderly (>75 years) and younger (≤75 years) patients?
Population
2,119 consecutive patients with objectively confirmed acute venous thromboembolism admitted to 25 Italian…
Design
Cohort
Authors
Discussion
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Implication
Supports age-differentiated VTE risks from immobilization; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=2,119)
Multicenter
Yes
Structured PICO
Do the major risk factors for venous thromboembolism differ between elderly (>75 years) and younger (≤75 years) patients?
P
Population
2,119 consecutive patients with objectively confirmed acute venous thromboembolism, of whom 20% were older than 75 years.
C
Comparator
Patients ≤75 years of age
O
Outcome
Prevalence and relative weight of major risk factors for venous thromboembolism at the time of the index event
Main Result
Odds Ratio: 2.46 (95% CI 1.85–3.27)
Severe medical disorders and immobilization are stronger risk factors for venous thromboembolism in elderly patients compared to younger patients, highlighting the need for adequate thromboprophylaxis in this population.
Cite This Study
Ageno et al. (2008) conducted an observational in acute venous thromboembolism (n=2,119). Elderly age (>75 years) vs. Younger age (≤75 years) was evaluated on Immobilization as an associated risk factor (OR 2.46, 95% CI 1.85-3.27). In patients with venous thromboembolism, elderly age (>75 years) was significantly associated with immobilization (OR 2.46; 95% CI 1.85-3.27) and severe medical disorders compared to younger patients.