Key result
4F-PCC without vitamin K drops INR to 1.8, allowing urgent surgery with minimal bleeding.
Why the study?
Does 4-factor prothrombin complex concentrate without vitamin K successfully reverse warfarin anticoagulation for emergent surgery in a patient at moderate-to-high risk for thromboembolism?
Case Report (n=1)
No
Does 4-factor prothrombin complex concentrate without vitamin K successfully reverse warfarin anticoagulation for emergent surgery in a patient at moderate-to-high risk for thromboembolism?
Administration of 4F-PCC without vitamin K successfully reversed warfarin for emergent surgery, allowing rapid return to therapeutic anticoagulation in a patient at high thromboembolic risk.
No takes yet. Share an insight, caveat, or question.
May support minimizing subtherapeutic time in select high-risk patients; leaves open bleeding safety for prospective evaluation.
Farley et al. (2016) conducted a case report in Anticoagulation reversal for urgent surgery (n=1). Four-factor prothrombin complex concentrate (4F-PCC) without vitamin K was evaluated on INR reversal and surgical bleeding. Administration of 4F-PCC without concurrent vitamin K successfully reversed warfarin anticoagulation, reducing INR from 3.2 to 1.8, and allowed for urgent surgery with minimal bleeding.
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