Key result
New non-radioactive high-throughput assay for chloride channels achieves successful validation with a ~0.68 Z-factor.
A new non-radioactive, high-throughput flux assay using atomic absorption spectroscopy was successfully developed and validated for studying endogenously expressed chloride channels in CHO-K1 cells.
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May accelerate in vitro chloride channel screening; hypothesis-generating and should not yet change practice.
Gill et al. (2006) studied Chloride channel physiology. HTS Flux Assay was evaluated on Assay validation (Z' factor and linear correlation). A new non-radioactive high-throughput flux assay for chloride channels was successfully developed and validated in a CHO-K1 cell line, demonstrating a Z' factor of 0.678.
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