Key result
Chronic lead exposure increases basal plasma renin activity in rats with variable effects in humans.
Why the study?
Does chronic lead exposure alter the renin-angiotensin system in animals and humans?
Does chronic lead exposure alter the renin-angiotensin system in animals and humans?
Chronic lead exposure exerts complex, time- and dose-dependent effects on the renin-angiotensin system, which may contribute to lead-induced hypertension.
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Variable human renin responses to lead caution against clinical extrapolation from rat models; leaves open mechanistic links to hypertension.
A. J. Vander (1988) conducted a review in Lead exposure. Lead exposure was evaluated on Plasma renin activity (PRA). Chronic lead exposure causing blood lead concentrations of 30 to 40 micrograms/dL increases basal plasma renin activity in rats, whereas human data show highly variable changes.
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