Key result
Ridogrel and cod liver oil preserve post-injury capillary perfusion in rats without altering visible emboli.
Why the study?
Does cod liver oil or Ridogrel improve microvascular perfusion after arterial injury in a rat model?
Population
Rats subjected to standardized microvascular injury on the right iliac artery to generate emboli
Comparison
Cod liver oil diet, Ridogrel, or a combination… vs Untreated controls
Design
Preclinical
Authors
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Hypothesis-generating for microvascular protection by Ridogrel or cod liver oil after arterial injury; leaves open any human translation.
Does cod liver oil or Ridogrel improve microvascular perfusion after arterial injury in a rat model?
In a rat model of arterial injury, Ridogrel and cod liver oil protected microcirculation, with Ridogrel's effects mediated by A-3 vasodilatation.
O’Shaughnessy et al. (1997) studied Microvascular injury and thromboembolic events (n=28). Ridogrel and/or cod liver oil vs. Untreated controls was evaluated on Capillary perfusion and arteriole diameters. Ridogrel and cod liver oil preserved or increased capillary perfusion after arterial injury in rats compared to untreated controls, without changing the number of visible emboli.
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