Why the study?
Does high-dose insulin therapy improve clinical outcomes in a patient with refractory shock from calcium channel blocker and oral hypoglycemic agent overdose?
Case Report (n=1)
No
Does high-dose insulin therapy improve clinical outcomes in a patient with refractory shock from calcium channel blocker and oral hypoglycemic agent overdose?
High-dose insulin therapy may be an effective rescue treatment for refractory shock secondary to calcium channel blocker and oral hypoglycemic agent overdose.
Should not yet change overdose protocols; extends anecdotal HDI support but leaves efficacy unproven in controlled studies.
We report a case of polypharmacy overdose involving a calcium (Ca) channel blocker and an oral hypoglycemic agent, where conventional therapies failed to obtain the desired clinical outcome. High-dose insulin (HDI) therapy, a promising treatment regime in this regard, was carried out for our patient, and her condition improved over the subsequent days.
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Vinayak et al. (2025) conducted a case report in Refractory shock following calcium channel blocker and oral hypoglycemic agent overdose (n=1). High-dose insulin therapy was evaluated on Hemodynamic recovery (blood pressure and heart rate improvement).
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