Key result
High-dose IV insulin and glucose successfully manages massive CCB overdose resistant to conventional support.
Why the study?
Does high-dose intravenous insulin and glucose infusion improve acute management in a patient with massive calcium channel blocker overdose resistant to conventional support?
Does high-dose intravenous insulin and glucose infusion improve acute management in a patient with massive calcium channel blocker overdose resistant to conventional support?
High-dose intravenous insulin and glucose infusion can be a beneficial rescue therapy in the acute management of massive calcium channel blocker overdose resistant to conventional support.
High-dose insulin may aid acute management of refractory cardiac drug overdose; hypothesis-generating for long-term cardiac outcomes.
We describe a case of massive overdosage with cardiac medications that proved resistant to conventional support, including fluid replacement, inotropes, mechanical ventilation, cardiac pacing and haemofiltration. The use of a high-dose insulin and glucose infusion proved to be beneficial in the acute management although the patient has been left with significant impairment of cardiac function.
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Rosser et al. (2012) studied this question. High-dose intravenous insulin and glucose infusion proved beneficial in the acute management of a massive calcium channel blocker overdose resistant to conventional support.
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