Key result
Olive leaves protect against isoproterenol-induced MI and oxidative heart damage in male rats.
Why the study?
Does olive leaves administration improve cardiac necrosis markers and oxidative damage in rats with isoproterenol-induced myocardial infarction?
Does olive leaves administration improve cardiac necrosis markers and oxidative damage in rats with isoproterenol-induced myocardial infarction?
Olive leaves administration demonstrates protective effects against isoproterenol-induced myocardial infarction and oxidative damage in a rat model.
Olive leaf extract attenuated experimental cardiac injury in rats; hypothesis-generating and requires human trials before any clinical consideration.
AimThe present study aimed to evaluate the protective effect and treatment of olive leaves administration on cardiac necrosis markers, some electrolytes, and cardiac tissue antioxidants in myocardial necrosis induced experimentally in rats by subcutaneous injection of isoproterenol (ISO).ResultsISO-induced myocardial infarction in male rats resulted in a significant increase in creatine kinase, creatine kinase MB, lactate dehydrogenase, aspartate aminotransferase, glucose, potassium, and phosphorus in serum, in addition to a significant increase in glucose-6-phosphate dehydrogenase in red blood cells. In addition, it resulted in a significant decrease in serum calcium and sodium in serum. Furthermore, this study demonstrated that there was a significant decrease in heart tissue superoxide dismutase and a significant decrease in catalase activity, as well as a significant increase in heart l-malondialdehyde levels, in ISO-injected rats.ConclusionThis study shows that that olive leaves administration is effective against myocardial infarction and oxidative damage in heart tissue induced by ISO in rats.
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Mohammed et al. (2016) studied Myocardial infarction (experimentally induced). Olive leaves administration vs. Isoproterenol-injected rats without treatment was evaluated on Cardiac necrosis markers, electrolytes, and cardiac tissue antioxidants. Olive leaves administration is effective against myocardial infarction and oxidative damage in heart tissue induced by isoproterenol in male rats.
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