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March 1, 1980American Journal of Health-System Pharmacy

Improving Medication Compliance by Counseling and Special Prescription Container

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Key result

Special medication containers improve compliance and lower diastolic BP in hypertensive patients.

  • P<0.01
  • n=100

Why the study?

Do patient counseling and special medication containers improve medication compliance and blood pressure in hypertensive patients?

Population

100 hypertensive patients attending a hypertension clinic, prescribed two or more medications per day, and…

Comparison

Disease and medication counseling, use of a… vs Control group receiving neither counseling nor…

Design

RCT, assigned randomly to one of four groups

Follow-up

three-month period

Authors

TRTerry L. RehderLMLinda K. McCoyBBBarry BlackwellAdvanced Pharma

Discussion

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Implication

Supports special containers in hypertension management; confirms RCT benefits for adherence and diastolic BP control.

Study Design

Type

RCT (n=100)

Randomization

randomly assigned

Structured PICO

Do patient counseling and special medication containers improve medication compliance and blood pressure in hypertensive patients?

P
Population
100 hypertensive patients prescribed two or more daily medications, followed for 3 months.
I
Intervention
Disease and medication counseling, use of a special medication container (with separate compartments for each dose, labeled with day and time), or a combination of both.
C
Comparator
Control group receiving neither counseling nor special medication container.
O
Outcome
Medication compliance (measured by attendance and dosage-unit count) and arterial blood pressure readings over a three-month period.surrogate

Main Result

p-value: p=<0.01

Special medication containers and patient counseling significantly improve medication compliance and can lower diastolic blood pressure in hypertensive patients on multiple medications.

Cite This Study

Rehder et al. (1980) conducted an RCT in Hypertension (n=100). Patient counseling and special medication container vs. Control was evaluated on Medication compliance (attendance, dosage-unit count, and arterial blood pressure readings) (p=<0.01). Special medication containers, with or without counseling, significantly improved medication compliance (P<0.01) and decreased diastolic blood pressure (P<0.02) in hypertensive patients.

synapsesocial.com/papers/6aa72e7b834face64f9509d1https://doi.org/10.1093/ajhp/37.3.379

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of a Pharmacist‐Led Drug Counseling on Enhancing Antihypertensive Adherence and Blood Pressure Control: A Randomized Controlled Trial2013 · 41 citations
  2. 2Antihypertensive Medication-Taking Investigation of a Simple Regimen1993 · 61 citations
  3. 3Impact of a Pill Box Clinic to Improve Systolic Blood Pressure in Veterans with Uncontrolled Hypertension Taking 3 or More Antihypertensive Medications2014 · 18 citations
  4. 4To improve medication adherence in hypertensive patients: A cross section Study2022
  5. 5Compliance and the treatment of hypertension: where are we now?2007 · 3 citations