What question did this study set out to answer?

To identify stage-specific shifts in fecal microbiota composition across the progression from healthy tissue to preneoplastic lesions and malignant colorectal cancer.

July 3, 2018Scientific ReportsOpen Access

Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis

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Authors

GMGiorgia MoriUniversity of Parma SRSimone RampelliUniversity of Bologna BOBéatrice Silvia OrenaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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Implication

Cross-sectional study reveals stage-specific fecal microbiota shifts in patients with colorectal lesions, highlighting distinct microbial biomarkers for early and malignant stages.

Key Points

To identify stage-specific shifts in fecal microbiota composition across the progression from healthy tissue to preneoplastic lesions and malignant colorectal cancer.
Extracted bacterial DNA from fecal samples collected from healthy individuals and patients with various preneoplastic and neoplastic colorectal lesions.
Profiled microbial communities using 16S rRNA gene sequencing to compare taxonomic distributions across disease stages.
Bacteria from the Firmicutes and Actinobacteria phyla, particularly the Lachnospiraceae family, were selectively enriched in patients with preneoplastic lesions, including adenomas and hyperplastic polyps.
Members of the Proteobacteria phylum, specifically the families Alcaligeneaceae (predominantly Sutterella) and Enterobacteriaceae (predominantly Escherichia/Shigella), were specifically associated with malignant carcinomas.

Cite This Study

Mori et al. (2018) studied this question.

synapsesocial.com/papers/6aa72ef3bb64cafef81b3a95 https://doi.org/10.1038/s41598-018-28671-9

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Implication

Cross-sectional study reveals stage-specific fecal microbiota shifts in patients with colorectal lesions, highlighting distinct microbial biomarkers for early and malignant stages.

Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Shifts of Faecal Microbiota During Sporadic Colorectal Carcinogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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