Key result
Serotonin syndrome linked to focal seizure complication requiring early antiepileptic treatment.
Why the study?
Serotonin syndrome is life-threatening, and seizures can complicate management and delay diagnosis.
Case Report (n=1)
Focal seizures can be a manifestation of serotonin syndrome and may require a short course of antiepileptics in addition to supportive care.
Raises awareness of seizures in serotonin syndrome; case report leaves open antiepileptic role without further evidence.
Serotonin syndrome is a life-threatening condition. Seizure is one of the complications of serotonin syndrome that may delay diagnosis and complicate management. We report a patient who had a focal seizure with abnormal electroencephalogram in the setting of serotonin syndrome with no prior history of epilepsy or seizure-provoking factors (fever, electrolyte abnormalities, specific medication combinations, and specific medication overdosing). Recognition of seizure as a symptom of serotonin syndrome is important for early treatment and avoidance of long-term consequences. Treatment of serotonin syndrome is mostly supportive. However, a short course of antiepileptics may be needed if these patients develop seizures.
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Almallouhi et al. (2019) conducted a case report in Serotonin syndrome (n=1). Serotonin syndrome was evaluated on Focal seizure. A patient developed a focal seizure with an abnormal electroencephalogram as a complication of serotonin syndrome, highlighting the need for early recognition and potential antiepileptic treatment.
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