What question did this study set out to answer?

Determine whether resveratrol reduces blood cholesterol levels by stimulating CYP7A1-mediated bile acid synthesis through LXRα signaling.

January 1, 2012Lipids in Health and DiseaseOpen Access

Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice

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Determine whether resveratrol reduces blood cholesterol levels by stimulating CYP7A1-mediated bile acid synthesis through LXRα signaling.
Administered resveratrol (200 mg/kg per day) for 8 weeks to C57BL/6J mice fed a high-fat diet to evaluate body weight, serum lipids, liver lipid content, and bile acid pool size.
Investigated hepatic CYP7A1 expression, enzymatic activity, and LXRα pathway activation in vivo and in HepG2 hepatocytes, including testing with the LXRα inhibitor geranylgeranyl pyrophosphate.
Resveratrol significantly decreased body weight gain, liver weight, and hepatic cholesterol accumulation while expanding bile acid pool size and improving serum lipid profiles in high-fat diet-fed mice.
Resveratrol substantially upregulated hepatic CYP7A1 mRNA, protein expression, and enzyme activity in mice and induced time- and dose-dependent CYP7A1 and LXRα activation in HepG2 cells, which was blocked by LXRα inhibition.

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Implication

Preclinical study reveals that resveratrol lowers cholesterol by activating CYP7A1 via LXRα pathways in obese mice, indicating a potential target for treating dyslipidemia.

Cite This Study

Chen et al. (2012) studied this question.

synapsesocial.com/papers/6aa730d30e83de72646df35b https://doi.org/10.1186/1476-511x-11-56

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Implication

Preclinical study reveals that resveratrol lowers cholesterol by activating CYP7A1 via LXRα pathways in obese mice, indicating a potential target for treating dyslipidemia.

Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice

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Discussion

Implication

Cite This Study

Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice

Key Points

Discussion

Implication

Cite This Study

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