Key result
Hemoglobin A1c levels were significantly inversely correlated with asymmetrical dimethylarginine levels in diabetic patients with normal glomerular filtration rates (r=-0.377, p<0.001).
Cross-Sectional (n=88)
Effect estimate: r=-0.377
p-value: p=<0.001
In diabetic patients with normal GFR, there is a significant inverse correlation between ADMA levels and HbA1c, indicating that ADMA levels are higher in those with better glycemic control.
Objective: The relationship of asymmetrical dimethylarginine (ADMA) and glycemic control in diabetes is not yet fully enlightened. We aim to investigate the association of ADMA and hemoglobin A1c (HbA1c) in normal glomerular filtration rate (GFR) diabetic patients. Methods: This cross sectional study included 88 diabetic patients whose GFRs were in reference range. 2 different HbA1c values; current (cHbA1c) and mean of 4 successive measurements with 3 months intervals (mHbA1c) were used. The association of ADMA with HbA1c levels and other clinical characteristics of patients were evaluated. Results: We found significant inverse correlations between ADMA and both current (r =-0,354, p=0,001) and mean HbA1c(r=-0,377, p=0,000) levels. In multiple lineer regression analyses mHbA1c, glucose and duration of diabetes ( R²=0,343, p=0,000) or cHbA1c, glucose and duration of diabetes (R²=0,318 p<0,001)were predictive variables for ADMA
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Madenci et al. (2013) conducted a cross-sectional in Diabetes (n=88). Hemoglobin A1c (HbA1c) was evaluated on Association of asymmetrical dimethylarginine (ADMA) with HbA1c levels (r=-0.377, p=<0.001). Hemoglobin A1c levels were significantly inversely correlated with asymmetrical dimethylarginine levels in diabetic patients with normal glomerular filtration rates (r=-0.377, p<0.001).
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