Key result
CAD and atherosclerosis risk factors linked to ~40% lower flow-mediated dilation versus healthy controls.
Observational (n=123)
Absolute Event Rate: 8.6% vs 14.3%
p-value: p=<0.001
Endothelial function measured by FMD is significantly decreased in patients with CAD or atherosclerosis risk factors, and an FMD cutoff of 11.5% may help identify individuals at risk.
FMD reduction signals endothelial impairment in CAD; extends cross-sectional data but leaves prospective validation open.
Background:The purpose of this study was to evaluate the lower limit of the normal endothelial function, which may differentiate normal from abnormal values, and to evaluate changes of endothelial function according to ages. Materials and Methods:The study population were consisted of four groups:patients with coronary artery disease (CAD (group A, n=42, mean age:55 yrs, patients with one or more risk factors of atherosc- lerosis (group B, n=43, mean age:54 yrs, age- and sex-matched healthy subjects (group C, n=25, mean age:54 yrs), and healthy young subjects (group D, n=13, mean age:26 yrs. We measured the flow-mediated endothelium-dependent dilation (FMD of the brachial artery in all subjects using a high-resolution ultrasound and we analyzed the receiver operating characteristic (ROC curve. Results:The FMD of the A and B groups were significantly lowered (8.6±3.7% vs 9.9±4/5% (4.5% ? than the C (14.3±3.3%, p<0.001 or D groups (18.0±3.5%, p<0.001. The FMD level of 11.5% demonstrated a 76.3% sensitivity and 76% of specificity to differentiate normal endothelial function from abnormal one. The spearman correlation coefficient between age and FMD in groups C and D was -0.543 (p<0.001. Conclusions:Endothelial function was decreased in patients with CAD or risk factors of atherosclerosis. We observed an age-related tendency of a decline of endothelial function in healthy subjects. 11.5% FMD may be used to identify the person at risk of atherosclerosis. (Korean Circulation J 2001;31(6 :544-550
No takes yet. Share an insight, caveat, or question.
Park et al. (2001) conducted an observational in Coronary artery disease or risk factors of atherosclerosis (n=123). Coronary artery disease or atherosclerosis risk factors vs. Healthy subjects was evaluated on Flow-mediated endothelium-dependent dilation (FMD) of the brachial artery (p=<0.001). Coronary artery disease and atherosclerosis risk factors were associated with significantly lower flow-mediated dilation (8.6% and 9.9%) compared to healthy age-matched controls (14.3%, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: