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September 1, 2026Diabetes and Vascular Disease ResearchOpen Access

Specific circulating LPEs link to greater PCAT inflammation and CAD burden in T2DM.

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Why the study?

T2DM involves alterations in lipid metabolism beyond conventional cholesterol profiles, motivating investigation into whether specific plasma lipidomic signatures relate to PCAT inflammation and CAD burden.

Are circulating lysophosphatidylethanolamine species associated with pericoronary adipose tissue inflammation and coronary atherosclerotic burden in type 2 diabetes?

Population

176 T2DM participants from the GADA study

Comparison

Plasma lipid species levels associated with FAI and CAD burden

Design

Cross-sectional analysis

Key result

In 176 T2DM patients, circulating LPE (18:1), LPE (20:4), and LPE (18:2) were independently associated with both pericoronary adipose tissue inflammation and coronary artery disease burden.

Authors

DDDaopeng DaiSCShuai ChenQLQingrun Li

Discussion

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Overview

LPEs may identify high-risk T2DM patients; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=176)

Structured PICO

Are circulating lysophosphatidylethanolamine species associated with pericoronary adipose tissue inflammation and coronary atherosclerotic burden in type 2 diabetes?

P
Population
176 participants with type 2 diabetes mellitus from the GADA study.
O
Outcome
Pericoronary adipose tissue (PCAT) inflammation measured by fat attenuation index (FAI) and coronary artery disease (CAD) burden measured by Gensini/SYNTAX scoressurrogate

Circulating LPE species (18:1, 20:4, 18:2) are identified as potential lipid-inflammatory biomarkers associated with pericoronary adipose tissue inflammation and coronary atherosclerotic burden in patients with type 2 diabetes.

Cite This Study

Dai et al. (2026) conducted a cross-sectional in Type 2 diabetes mellitus (n=176). Circulating lysophosphatidylethanolamine (LPE) species was evaluated on Pericoronary adipose tissue (PCAT) inflammation and coronary artery disease (CAD) burden. In 176 T2DM patients, circulating LPE (18:1), LPE (20:4), and LPE (18:2) were independently associated with both pericoronary adipose tissue inflammation and coronary artery disease burden.

synapsesocial.com/papers/6aa753631e479256cc188bcahttps://doi.org/10.1177/14791641261484961
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Lipidomics Profiles Highlight the Associations of the Dual Antioxidant/Pro-oxidant Molecules Sphingomyelin and Phosphatidylcholine with Subclinical Atherosclerosis in Patients with Type 1 Diabetes2023 · 17 citations
  2. 2Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients2023 · 24 citations
  3. 3Plasma Lipids Associated with Endothelial Dysfunction in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Lipidomic Analysis2026
  4. 4Association of serum lysophosphatidylcholine acyltransferase 3 levels with metabolic variables and risk of type 2 diabetes mellitus: A cross-sectional study2025
  5. 5Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Atrial Myocardium and Coronary Perivascular Adipose Tissue2023 · 3 citations