Why the study?
Are there sex-related differences in left-atrial low-voltage areas and atrial remodeling that explain atrial fibrillation susceptibility?
Comparison
Women vs men
Key result
Women had greater areas of left-atrial low-voltage, smaller atria, and smaller cardiomyocytes compared to men, despite no differences in the degree of atrial remodeling.
Authors
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May warrant sex-specific voltage thresholds during AF ablation; leaves open whether these substrate differences alter outcomes or guide therapy.
Are there sex-related differences in left-atrial low-voltage areas and atrial remodeling that explain atrial fibrillation susceptibility?
This commentary highlights that women exhibit greater left-atrial low-voltage areas and smaller atria and cardiomyocytes than men, providing mechanistic insights into sex differences in atrial fibrillation.
Stanley Nattel (2025) studied this question. Women had greater areas of left-atrial low-voltage, smaller atria, and smaller cardiomyocytes compared to men, despite no differences in the degree of atrial remodeling.