Key result
Acute overdose of drugs like sotalol and haloperidol is linked to ~13% incidence of severe QTc prolongation.
Why the study?
Severe QT prolongation predicts adverse cardiovascular events in acute drug overdose, but drug-specific causes in this setting remain unclear.
Which specific drugs are associated with severe QT prolongation following acute drug overdose in adults?
Population
6473 adults receiving medical toxicology consultation for acute drug overdose across >50 US hospital sites
Comparison
Drug-specific exposures following acute drug overdose
Design
Prospective multicenter cohort study
Authors
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May support ECG monitoring in these overdoses; extends associations but leaves open prospective outcome studies.
Cohort (n=6,473)
Yes
Which specific drugs are associated with severe QT prolongation following acute drug overdose in adults?
Acute overdose of specific drugs, including certain antidepressants, antipsychotics, and sodium channel blockers, is significantly associated with severe QT prolongation, warranting close cardiac monitoring.
Campleman et al. (2020) conducted a cohort in Acute drug overdose (n=6,473). Specific drugs (e.g., sotalol, amitriptyline, haloperidol, ondansetron) was evaluated on Severe QT prolongation (SQTP) defined as QTc ≥ 500 milliseconds. Specific drugs including sotalol, amitriptyline, and haloperidol were associated with increased adjusted odds of severe QT prolongation, which occurred in 13% of acute drug overdose patients.
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