What question did this study set out to answer?

To determine whether human milk oligosaccharide profiles vary across diverse geographic populations of healthy women and evaluate associations with maternal characteristics.

March 30, 2017American Journal of Clinical NutritionOpen Access

What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically ,

View Full Paper

Ask AI

Bookmark

Authors

CMCourtney L. Meehan MMMark A. McGuire MMMark A. McGuire

Discussion

Member takes

Overview

Randomized trial reveals geographic variation in human milk oligosaccharide profiles among healthy breastfeeding women, suggesting environmental influences on synthesis.

Key Points

To determine whether human milk oligosaccharide profiles vary across diverse geographic populations of healthy women and evaluate associations with maternal characteristics.
Interventional study (NCT02670278) evaluating milk samples from 410 healthy, breastfeeding women across 11 international cohorts.
Human milk oligosaccharides were quantified using high-performance liquid chromatography and compared with maternal anthropometric and reproductive indexes.
Cohort origin had a significant effect on concentrations of almost all evaluated human milk oligosaccharides (P < 0.05).
Mean 3-fucosyllactose was >4-fold higher in Sweden than in rural Gambia (473 ± 55 vs 103 ± 16 nmol/mL; P < 0.05), whereas disialyllacto-N-tetraose concentrations were highest in rural Gambia (870 ± 68 nmol/mL) and lowest in Sweden (216 ± 14 nmol/mL; P < 0.05).
Maternal age, time postpartum, weight, and body mass index correlated with several oligosaccharides, and distinct profiles emerged between ethnically similar groups residing in different locations.

Cite This Study

Meehan et al. (2017) studied this question.

synapsesocial.com/papers/6aa75d6937cfa9e88af63d60 https://doi.org/10.3945/ajcn.116.139980

View Full Paper

Ask AI

Bookmark

March 30, 2017American Journal of Clinical NutritionOpen Access

What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically ,

View Full Paper

Ask AI

Bookmark

Authors

CMCourtney L. Meehan MMMark A. McGuire MMMark A. McGuire

Discussion

Member takes

Overview

Randomized trial reveals geographic variation in human milk oligosaccharide profiles among healthy breastfeeding women, suggesting environmental influences on synthesis.

Key Points

To determine whether human milk oligosaccharide profiles vary across diverse geographic populations of healthy women and evaluate associations with maternal characteristics.
Interventional study (NCT02670278) evaluating milk samples from 410 healthy, breastfeeding women across 11 international cohorts.
Human milk oligosaccharides were quantified using high-performance liquid chromatography and compared with maternal anthropometric and reproductive indexes.
Cohort origin had a significant effect on concentrations of almost all evaluated human milk oligosaccharides (P < 0.05).
Mean 3-fucosyllactose was >4-fold higher in Sweden than in rural Gambia (473 ± 55 vs 103 ± 16 nmol/mL; P < 0.05), whereas disialyllacto-N-tetraose concentrations were highest in rural Gambia (870 ± 68 nmol/mL) and lowest in Sweden (216 ± 14 nmol/mL; P < 0.05).
Maternal age, time postpartum, weight, and body mass index correlated with several oligosaccharides, and distinct profiles emerged between ethnically similar groups residing in different locations.

Cite This Study

Meehan et al. (2017) studied this question.

synapsesocial.com/papers/6aa75d6937cfa9e88af63d60 https://doi.org/10.3945/ajcn.116.139980

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark