May 1, 1981Clinical Pharmacology & Therapeutics
Hemodynamic effects of morphine and nalbuphine in acute myocardial infarction
Key result
Nalbuphine lowers heart rate and cardiac index without impairing cardiac pump function compared to morphine.
- n=15
Why the study?
Does nalbuphine compared to morphine alter hemodynamic parameters in patients with acute myocardial infarction?
Population
15 patients with acute myocardial infarction and normal group mean hemodynamic function, average age 56.2…
Comparison
Nalbuphine vs Morphine
Design
RCT, randomized, double-blind
Follow-up
1 hour
Authors
Discussion
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Implication
Supports nalbuphine consideration for analgesia in AMI; extends randomized hemodynamic data versus morphine.
Study Design
Type
RCT (n=15)
Blinding
Double-blind
Randomization
randomized
Structured PICO
Does nalbuphine compared to morphine alter hemodynamic parameters in patients with acute myocardial infarction?
P
Population
15 patients (average age 56.2 years, 27% female) with acute myocardial infarction and normal group mean hemodynamic function, evaluated over 1 hour.
I
Intervention
Nalbuphine
C
Comparator
Morphine
O
Outcome
Hemodynamic effects (heart rate, arterial pressures, cardiac index, systemic vascular resistance) during a 1-hr evaluationsurrogate
Nalbuphine produces minor hemodynamic changes without clinically important deleterious effects on cardiac pump function, suggesting it merits further investigation as an analgesic in acute myocardial infarction.
Cite This Study
Lee et al. (1981) conducted an RCT in acute myocardial infarction (n=15). Nalbuphine vs. Morphine was evaluated on Hemodynamic effects. Nalbuphine decreased heart rate and cardiac index while increasing systemic vascular resistance, but showed no clinically important deleterious effects on cardiac pump function compared to morphine.