Key result
The Brussels Integrated ADL Inventory plus age correctly predicts cognitive status in ~63% of cases.
Why the study?
Assessing activities of daily living is essential for early diagnosis of neurocognitive disorders, but the most common tools are limited in the diagnostic process.
Does the Brussels Integrated Activities of Daily Living Inventory (BIA) accurately discriminate between cognitively healthy older persons, those with mild cognitive impairment, and those with Alzheimer's disease?
Cross-Sectional (n=130)
No
Does the Brussels Integrated Activities of Daily Living Inventory (BIA) accurately discriminate between cognitively healthy older persons, those with mild cognitive impairment, and those with Alzheimer's disease?
The instrumental ADL component of the Brussels Integrated Activities of Daily Living Inventory, along with age, can moderately discriminate between cognitively healthy individuals, those with MCI, and those with Alzheimer's disease.
May aid cognitive screening in older adults; hypothesis-generating and requires prospective validation before clinical adoption.
The Assessment of Activities of Daily Living (ADL) is paramount to ensure the accurate early diagnosis of neurocognitive disorders. Unfortunately, the most common ADL tools are limited in their use in a diagnostic process. Hence, we set out to validate a tool to evaluate basic (b-), instrumental (i-), and advanced (a-) ADL called the Brussels Integrated Activities of Daily Living Inventory (BIA). At the geriatric day hospital of the University Hospital Brussels (Belgium) older persons (65+) labelled as Cognitively Healthy Persons (CHP) (n = 47), having a Mild Cognitive Impairment (MCI) (n = 39), and having Alzheimer’s disease (AD) (n = 44) underwent a diagnostic procedure for neurocognitive disorders. Additionally, the BIA was carried out. An exploration using both (cumulative) logistic regressions and conditional inference trees aimed to select the most informative scales to discriminate between the HCP, persons with MCI and AD. The distinction between CHP and MCI and between MCI and AD was moderately successful with the i-ADLs, in addition to age. Therefore, it is advisable to conduct a multidomain assessment in which the i-ADL could serve as non-invasive and non-time-consuming screening, while the BIA might be useful for diagnostics and disease management.
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Vriendt et al. (2021) conducted a cross-sectional in Mild Cognitive Impairment and Alzheimer's Disease (n=130). Brussels Integrated Activities of Daily Living Inventory (BIA) vs. Clinical diagnosis (Cognitively Healthy vs MCI vs Alzheimer's Disease) was evaluated on Overall correctly predicted diagnosis across the three cognitive groups. The Brussels Integrated Activities of Daily Living Inventory, specifically the instrumental ADL indices combined with age, correctly predicted the diagnosis of cognitive status in 63% of cases, successfully distinguishing cognitively healthy persons from those with cognitive disorders.
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