Key result
Hypertensive disorders of pregnancy are linked to lower maternal renal artery Doppler indices vs normal pregnancies.
Why the study?
Do hypertensive disorders of pregnancy alter maternal renal artery Doppler blood flow velocity indices compared to normal pregnancy?
Observational (n=124)
Do hypertensive disorders of pregnancy alter maternal renal artery Doppler blood flow velocity indices compared to normal pregnancy?
Hypertensive disorders of pregnancy are associated with lower renal artery Doppler indices, suggesting altered renal autoregulation and challenging the concept of renal vasoconstriction in preeclampsia.
May support reevaluation of renal vasoconstriction in preeclampsia; hypothesis-generating and should not yet change practice.
OBJECTIVE: To investigate the effect of normal pregnancy and hypertensive disorders of pregnancy on the maternal renal artery Doppler blood flow velocity indices. METHODS: The patient material consisted of 30 normal pregnant women, 29 women with pregnancy induced hypertension, 43 women with preeclampsia and 22 pregnant women with chronic hypertension. Blood flow velocities in the segmental renal arteries from the right kidney were analysed by pulsed and color Doppler. The systolic/diastolic (s.d.) ratio, resistance index (RI) and pulsatility index (PI) were used for Doppler waveform analysis. RESULTS: In all of the groups of hypertensive pregnant women renal artery Doppler indices were significantly lower compared to the normal pregnant women group. There was a significant negative relationship between renal artery PI and mean arterial pressure in the preeclampsia group and in the chronic hypertension group. CONCLUSION: The present results demonstrate that the mechanism of renal autoregulation in preeclampsia might be altered, leaving glomerulus unprotected from increased blood pressure. It seems that the concept of renal vasoconstriction in preeclampsia might be disputed and needs further investigation.
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Kublickas et al. (1996) conducted an observational in Hypertensive disorders of pregnancy (n=124). Hypertensive disorders of pregnancy vs. Normal pregnancy was evaluated on Maternal renal artery Doppler blood flow velocity indices (systolic/diastolic ratio, resistance index, and pulsatility index). Hypertensive disorders of pregnancy were associated with significantly lower maternal renal artery Doppler indices compared to normal pregnancies.
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