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Antibodies directed against tumor associated antigen provides a means for delivering preferentially cytotoxic radionucleotides to the tumor tissue primary as well as its metastatic sites known as Zetotherapy or Radioimmunotherapy, The factor that can influence the effectiveness of radiation in the tumor compared with its effects on radio sensitive normal tissue depends upon specificity of antibody , other factor which can influence is the distribution of target energy in the tumor and host response to the injected foreign antibody There is a continue research/studies for more specific antibodies to target against targeting antigen present on tumor , the parallel growth of Genetic Engineering are geared towards the problem of reducing antigenecity of specific antibodies and reducing the mass of cancer antigen antibodies.
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Nahla A M Hamed (2023) studied this question.
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