Key result
Pituitary IGF system gene expression localizes to connective tissue rather than growth hormone synthesis sites.
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May not indicate direct IGF regulation of somatotrophs; leaves open paracrine roles in pituitary stroma for targeted study.
Bach et al. (1992) studied this question. In situ hybridization mapping of IGF system gene expression was evaluated on Localization of IGF system mRNA in the rat pituitary. IGF system gene expression is abundant in the rat pituitary but does not correlate with sites of growth hormone synthesis, localizing instead to connective tissue and support elements.
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