Key result
IGFBP-4 and -5 mRNAs are abundantly expressed in largely nonoverlapping discrete regions of the adult rat brain, with IGFBP-4 in hippocampal/cortical areas and IGFBP-5 in thalamic nuclei.
Population
Adult rat forebrain
Design
Preclinical
Authors
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Distinct rat brain IGFBP patterns suggest localized IGF modulation; leaves open human relevance and functional roles.
IGFBP-4 and -5 mRNAs have distinct, largely nonoverlapping expression patterns in the adult rat forebrain, suggesting region-specific modulation of IGF actions.
Stenvers et al. (1994) studied this question. In situ hybridization of IGFBP-4 and -5 mRNAs was evaluated on Localization of sites of IGFBP-4 and -5 mRNA expression in adult rat brain. IGFBP-4 and -5 mRNAs are abundantly expressed in largely nonoverlapping discrete regions of the adult rat brain, with IGFBP-4 in hippocampal/cortical areas and IGFBP-5 in thalamic nuclei.