June 1, 1991Journal of Biological ChemistryOpen Access

Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human

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Population

Adult rat serum, rat ovary library, human placenta library, and somatic cell hybrid DNAs of human and hamster

Design

Preclinical

Authors

SSShunichi ShimasakiUniversity of California, San Diego MSMotoyuki ShimonakaTokyo University of Science HZH.P. ZhangZhejiang University

Discussion

Member takes

Implication

Expands the IGFBP family; leaves open functional roles and therapeutic relevance in human disease.

Structured PICO

Population

Adult rat serum, rat ovary library, human placenta library, and somatic cell hybrid DNAs of human and hamster

Intervention

Protein isolation, molecular cloning, Northern analysis, and chromosomal localization

Outcome

Identification and characterization of insulin-like growth factor binding proteins (IGFBPs), including the cloning of a novel IGFBP-5

The study identifies and clones a novel insulin-like growth factor binding protein, IGFBP-5, expanding the known family of IGFBPs and mapping their chromosomal locations.

Cite This Study

Shimasaki et al. (1991) studied this question.

synapsesocial.com/papers/6a796ee71b9920df6d89028d https://doi.org/10.1016/s0021-9258(18)99272-0

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Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider