October 1, 1990Molecular EndocrinologyOpen Access

Molecular Cloning of the cDNAs Encoding a Novel Insulin-Like Growth Factor-Binding Protein from Rat and Human

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Population

Rat liver and human placenta, liver, and ovary cDNA libraries

Comparison

Molecular cloning and sequence analysis vs Previously characterized IGFBP-1, -2, and -3

Design

Preclinical

Authors

SSShunichi ShimasakiUniversity of California, San Diego FUFumiaki UchiyamaMochida Pharmaceutical (Japan)MSMotoyuki ShimonakaTokyo University of Science

Discussion

Member takes

Implication

Extends the IGFBP family with a structurally distinct member; leaves open its functional roles in IGF regulation.

Structured PICO

Population

Rat liver and human placenta, liver, and ovary cDNA libraries

Intervention

Molecular cloning and sequence analysis

Comparator

Previously characterized IGFBP-1, -2, and -3

Outcome

Identification and characterization of IGFBP-4 cDNA and amino acid sequencesurrogate

The study identifies and characterizes the cDNA and amino acid sequence of a novel insulin-like growth factor-binding protein, IGFBP-4, in rats and humans.

Cite This Study

Shimasaki et al. (1990) studied this question.

synapsesocial.com/papers/6a71a7726ceb2bbd16e0344a https://doi.org/10.1210/mend-4-10-1451

View Full Paper

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Bookmark

Molecular Cloning of the cDNAs Encoding a Novel Insulin-Like Growth Factor-Binding Protein from Rat and Human

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular Cloning of the cDNAs Encoding a Novel Insulin-Like Growth Factor-Binding Protein from Rat and Human

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider