Key result
Aripiprazole overdose in a toddler causes ~2 weeks of CNS depression without significant cardiovascular effects.
Why the study?
What are the clinical effects of aripiprazole overdose in a child?
Case Report (n=1)
What are the clinical effects of aripiprazole overdose in a child?
Aripiprazole overdose in a child can cause prolonged CNS depression without significant cardiovascular effects.
Answers are grounded in this paper and cite their sources.
May inform supportive care expectations after pediatric aripiprazole ingestion; single case leaves open generalizability and management guidance.
Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butyloxy}-3,4-dihydro-2(1H)-quinolinone, is an atypical antipsychotic medication inaugurating the newest class of atypical antipsychotics: the partial dopamine agonists. It has a particularly long half-life of elimination and variable metabolism secondary to genetic polymorphism. We report an unintentional overdose of 195 mg (17.1 mg/kg) of aripiprazole in a 2.5 year-old child. This patient exhibited CNS depression not requiring respiratory support and without significant cardiovascular effects. CNS effects persisted for almost 2 weeks postingestion.
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Seifert et al. (2005) conducted a case report in Aripiprazole overdose (n=1). Aripiprazole overdose was evaluated on Clinical effects of overdose. An unintentional overdose of 195 mg of aripiprazole in a 2.5 year-old child caused CNS depression lasting almost 2 weeks without requiring respiratory support or causing significant cardiovascular effects.
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