Key result
Incidental ingestion of 30 mg of aripiprazole in a healthy 3-year-old child resulted in prolonged lethargy, dystonia, and two witnessed seizures.
Case Report (n=1)
This is the first reported case of aripiprazole-induced seizures in a pediatric patient.
Alerts clinicians to possible seizure risk with aripiprazole; extends limited evidence on its neurological adverse effects.
Aripiprazole is an atypical antipsychotic medication that is a partial dopamine D(2) and serotonin 5-hydroxytryptamine (1A) receptor agonist and 5-hydroxytryptamine (2A) receptor antagonist. It has a safer profile compared to other antipsychotic medications with regard to its effect on weight, glucose tolerance, prolactin level, and cardiac conduction. The common neurological adverse effects include headache, agitation, insomnia, sleepiness, and extrapyramidal symptoms. Seizures have not been reported in the pediatric population and only twice in adult patients. Here, we report a case of a healthy 3-year-old child who experienced prolonged lethargy, dystonia, and 2 witnessed seizures after incidental ingestion of 30 mg of aripiprazole. To our knowledge, this is the first reported case of aripiprazole-induced seizures in a child.
No takes yet. Share an insight, caveat, or question.
Thabet et al. (2013) conducted a case report in Aripiprazole ingestion (n=1). Aripiprazole was evaluated on Seizures, lethargy, and dystonia. Incidental ingestion of 30 mg of aripiprazole in a healthy 3-year-old child resulted in prolonged lethargy, dystonia, and two witnessed seizures.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: