February 28, 2007Echocardiography
Assessment of Mitral Inflow During Standardized Valsalva Maneuver in Stratification of Diastolic Function
Key result
Valsalva maneuver lengthens atrial wave duration in pseudonormal filling but shortens it in normal subjects.
- P<0.05
- n=190
Why the study?
Does the standardized Valsalva maneuver help differentiate between normal and pseudonormal diastolic filling patterns on echocardiography?
Population
190 patients undergoing transthoracic echocardiography, with a subgroup comparison between 54 patients with…
Comparison
Standardized Valsalva maneuver during… vs Comparison between patients with normal versus…
Design
Cross-sectional
Authors
Discussion
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Implication
Changes in the duration and velocity-time integral of the atrial wave during the Valsalva maneuver can help differentiate pseudonormal from normal diastolic filling patterns on echocardiography.
Study Design
Type
Observational (n=190)
Structured PICO
Does the standardized Valsalva maneuver help differentiate between normal and pseudonormal diastolic filling patterns on echocardiography?
P
Population
190 patients (120 with coronary artery disease and 70 healthy subjects) evaluated by transthoracic echocardiography to assess mitral inflow during Valsalva maneuver.
E
Exposure
Standardized Valsalva maneuver during transthoracic echocardiography
C
Comparator
Comparison between patients with normal versus pseudonormal diastolic filling patterns
O
Outcome
Changes in mitral inflow parameters (early wave peak velocity, peak velocity of atrial wave, E/A ratio, duration and velocity-time integral of atrial wave) during Valsalva maneuversurrogate
Main Result
Absolute Event Rate: 20% vs -7%
p-value: p=< 0.05
Changes in the duration and velocity-time integral of the atrial wave during the Valsalva maneuver can help differentiate pseudonormal from normal diastolic filling patterns on echocardiography.
Cite This Study
Wierzbowska‐Drabik et al. (2007) conducted an observational in Left ventricular dysfunction (n=190). Pseudonormal filling pattern vs. Normal filling pattern was evaluated on Change in duration of atrial wave (DeltaAt) during Valsalva maneuver (p=< 0.05). During Valsalva maneuver, the duration of the atrial wave increased in patients with a pseudonormal filling pattern compared to a decrease in normal subjects (20 vs -7 msec; P<0.05).