Key result
NSRT linked to ~79% acute decrease in LVOT obstruction and shorter LV relaxation time.
Why the study?
Does nonsurgical septal reduction therapy acutely improve regional left ventricular asynchrony in patients with hypertrophic obstructive cardiomyopathy?
Population
22 patients with hypertrophic obstructive cardiomyopathy, mean age 56+/-17 years.
Comparison
Nonsurgical septal reduction therapy (NSRT) vs Baseline (pre-intervention measurements)
Design
Cohort
Follow-up
Acute (immediately before and after procedure)
Authors
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Acute hemodynamic improvement seen after nonsurgical septal reduction in HOCM; hypothesis-generating and leaves open need for randomized outcome trials.
Observational (n=22)
Does nonsurgical septal reduction therapy acutely improve regional left ventricular asynchrony in patients with hypertrophic obstructive cardiomyopathy?
Absolute Event Rate: 12% vs 57%
p-value: p=<0.05
Nonsurgical septal reduction therapy acutely improves left ventricular regional asynchrony, which correlates with improved left ventricular relaxation in patients with hypertrophic obstructive cardiomyopathy.
Park et al. (2002) conducted an observational in Hypertrophic Obstructive Cardiomyopathy (n=22). Nonsurgical septal reduction therapy vs. Baseline (before therapy) was evaluated on Left ventricular outflow tract obstruction (mm Hg) (p=<0.05). Nonsurgical septal reduction therapy acutely reduced left ventricular outflow tract obstruction from 57 to 12 mm Hg and shortened the time constant of LV relaxation (P<0.05).
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