Key result
Recombinant erythropoietin induces polycythemia but fails to alter pulmonary eNOS expression or perfusate nitrite levels.
Authors
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EPO does not appear to modulate pulmonary eNOS/NO in this model; leaves open relevance to pulmonary vascular tone in vivo.
Walker et al. (2000) studied Polycythemia. human recombinant erythropoietin (rEpo) vs. vehicle was evaluated on lung eNOS levels and perfusate nitrite/nitrate concentration. Recombinant erythropoietin induced polycythemia (hematocrit 65.8% vs 45.1%) but did not alter pulmonary eNOS expression or perfusate nitrite/nitrate concentration compared with vehicle.
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