Key result
Complex T-wave morphology parameters on BSPM predict arrhythmic events after recent MI.
Why the study?
Do T-wave morphology parameters from body surface potential mapping predict arrhythmic events in patients with recent MI and cardiac dysfunction?
Cohort (n=158)
Do T-wave morphology parameters from body surface potential mapping predict arrhythmic events in patients with recent MI and cardiac dysfunction?
Complex T-wave morphology derived from body surface potential mapping serves as an independent predictor of arrhythmic events in patients with recent myocardial infarction and cardiac dysfunction.
T-wave morphology parameters may refine post-MI arrhythmia risk assessment; leaves open whether BSPM adds incremental value beyond standard ECG in larger cohorts.
AIMS: Heterogeneous ventricular repolarization is associated with sudden cardiac death after myocardial infarction (MI). This prospective study investigated repolarization disparity with parameters based on T-wave morphology in body surface potential mapping (BSPM) in the assessment of arrhythmia risk in patients with a recent MI and cardiac dysfunction. METHODS AND RESULTS: Patients (n = 158) had 120-lead BSPM and 12-lead electrocardiogram (ECG) registered soon after acute MI. Principal component analysis (PCA) of the T-wave and T-wave vector loop descriptors were applied to compute parameters describing T-wave morphology and its variation. The study endpoints were arrhythmic events and all-cause mortality. During a mean follow-up of 50 months, 30 patients (19%) died and 16 (10%) had an arrhythmic event. Most of the parameters differed significantly between patients with and without arrhythmic events. In univariate analysis, T-wave vector loop length (TLL) and PCA parameter PCA(3) in BSPM and TLL in ECG were significant predictors of arrhythmic events. In multivariate analysis including several clinical variables, these parameters also showed an independent prediction, with parameters in BSPM performing somewhat better. None of the parameters predicted all-cause mortality. CONCLUSION: Complex T-wave morphology in BSPM is a marker of arrhythmia propensity in patients with a recent MI and cardiac dysfunction.
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Korhonen et al. (2009) conducted a cohort in Recent myocardial infarction and cardiac dysfunction (n=158). Complex T-wave morphology in body surface potential mapping (BSPM) was evaluated on Arrhythmic events and all-cause mortality. Complex T-wave morphology parameters in body surface potential mapping, such as T-wave vector loop length, were significant independent predictors of arrhythmic events after recent MI.
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