Key result
Higher intra-abdominal fat links to ~5% greater risk of metabolic syndrome components per 10 cm2.
Why the study?
Does intra-abdominal fat area predict the new onset of metabolic syndrome components in healthy Japanese individuals?
Population
1,380 Japanese subjects with no metabolic syndrome components at baseline, selected from 25,255 subjects…
Design
Cohort
Follow-up
mean 3.6 years
Authors
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May inform early risk stratification in Japanese adults; leaves open whether IAFA adds value beyond BMI in prospective trials.
Cohort (n=1,380)
No
Does intra-abdominal fat area predict the new onset of metabolic syndrome components in healthy Japanese individuals?
Hazard Ratio: 1.05 (95% CI 1.03–1.07)
p-value: p=<0.001
Intra-abdominal fat area measured by CT is an independent predictor for the development of metabolic syndrome components, even in non-obese individuals.
Nakao et al. (2012) conducted a cohort in Healthy individuals without metabolic syndrome components (n=1,380). Intra-abdominal fat area (IAFA) vs. Lower IAFA was evaluated on New onset of one of three metabolic syndrome components (high blood pressure, dyslipidemia, or hyperglycemia) (HR 1.05, 95% CI 1.03-1.07, p=<0.001). Intra-abdominal fat area was significantly associated with the new onset of metabolic syndrome components, with a hazard ratio of 1.05 per 10 cm2 increase, independent of body mass index.
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