Key result
Tranexamic acid controls severe bleeding and normalizes fibrinogen in 2 patients with aortic disease-induced fibrinolysis.
Why the study?
Chronic disseminated intravascular coagulation associated with aortic aneurysm or dissection commonly presents with bleeding symptoms due to enhanced fibrinolysis, necessitating management strategies in non-surgical candidates.
Does tranexamic acid relieve bleeding tendency in patients with severe hemorrhagic complications due to aortic disease and DIC?
Case Report (n=2)
No
Does tranexamic acid relieve bleeding tendency in patients with severe hemorrhagic complications due to aortic disease and DIC?
Tranexamic acid may be a safe prophylactic option to manage severe bleeding tendencies caused by excessive fibrinolysis in non-surgical patients with aortic disease.
Answers are grounded in this paper and cite their sources.
May support tranexamic acid for rare aortic fibrinolysis bleeding; hypothesis-generating, needs controlled trials before adoption.
Disseminated intravascular coagulation (DIC) is characterized by systemic activation of coagulation pathway which can lead to thrombosis and bleeding. Chronic DIC associated with aortic aneurysm or dissection commonly presents with bleeding symptoms with variable severity due to enhanced fibrinolysis. Patients with unexplained bleeding diathesis with DIC should include aortic disease as one of the differential diagnoses. This paper reports two patients with severe hemorrhagic complications due to aortic disease. Long-term prophylactic treatment is recommended if the underlying aortic disease cannot be surgically managed. Tranexamic acid is a potentially safe option to relieve bleeding tendency.
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Yip et al. (2020) conducted a case report in Disseminated intravascular coagulation with excessive fibrinolysis secondary to aortic disease (n=2). Tranexamic acid was evaluated on Bleeding tendency and fibrinogen levels. Tranexamic acid successfully controlled severe bleeding tendency and normalized fibrinogen levels in two non-surgical patients with excessive fibrinolysis secondary to aortic disease.
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