Clinically overt disseminated intravascular coagulation occurred preoperatively in only 4% of patients with aortic aneurysms, though 39% had elevated fibrin split products.
Cohort (n=76)
Clinically overt DIC is rare (4%) in preoperative patients with aortic aneurysms and is primarily associated with extensive thoracoabdominal aneurysms, despite frequent laboratory abnormalities.
A prospective study of 76 preoperative patients with aortic aneurysms was undertaken to determine the true incidence of associated disseminated intravascular coagulation (DIC). Although 39% of the patients showed a notable elevation of the fibrin split products level, only three had thrombocytopenia and a clinical bleeding diathesis, as well. Thus, clinically overt DIC occurred preoperatively in only 4% of the patients. All three patients had extensive aneurysms that involved the thoracoabdominal aorta. Preoperative fibrinogen levels in this series tended to be high-normal or elevated and were not good indicators of underlying excessive fibrinolysis. Hemostatic abnormalities, such as ecchymoses and petechiae, may be the key to the clinical diagnosis of DIC in preoperative patients with aortic aneurysms.
Daniel F. Fisher (1983) conducted a cohort in Aortic aneurysms (n=76). Aortic aneurysms was evaluated on Incidence of clinically overt disseminated intravascular coagulation (DIC). Clinically overt disseminated intravascular coagulation occurred preoperatively in only 4% of patients with aortic aneurysms, though 39% had elevated fibrin split products.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: