Key result
Advanced diagnostics help characterize acute antibody-mediated rejection but targeted immunosuppression efficacy remains unproven.
Population
Heart transplant recipients with acute antibody-mediated rejection (AMR)
Design
Review
Authors
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May aid acute AMR characterization in heart transplant; leaves B-lymphocyte targeted and mTOR inhibitor efficacy unproven.
Advances in diagnostic techniques like C4d deposition and flow cytometry for anti-HLA antibodies assist in characterizing acute antibody-mediated rejection in heart transplantation, though optimal immunosuppressive strategies remain to be proven.
Uber et al. (2007) conducted a review in Acute antibody-mediated rejection in heart transplantation. Advances in diagnostic techniques assist in characterizing acute antibody-mediated rejection, though the efficacy of B-lymphocyte targeted immunosuppression and m-TOR inhibitors remains to be proven.
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