Key result
Inactivated COVID-19 vaccine linked to AMI potentially due to Type II Kounis syndrome.
Why the study?
Acute myocardial infarction is a rare adverse event after COVID-19 vaccination, requiring greater clinician awareness of its presentation and underlying mechanisms.
Case Report (n=1)
Clinicians should be aware of the rare possibility of acute myocardial infarction following COVID-19 vaccination, potentially due to Type II Kounis syndrome in patients with underlying coronary artery disease.
A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) is a kind of rare adverse event after COVID-19 vaccination. Herein, we present a case of an 83-year-old male who suffered cold sweat ten minutes after the first inactivated COVID-19 vaccination and AMI one day later. The emergency coronary angiography showed coronary thrombosis and underlying stenosis in his coronary artery. Type II Kounis syndrome might be a potential mechanism, which is manifested as coronary thrombosis secondary to allergic reactions in patients with underlying asymptomatic coronary heart disease. We also summarize the reported AMI cases post COVID-19 vaccination, as well as overview and discuss the proposed mechanisms of AMI after COVID-19 vaccination, thus providing insights for clinicians to be aware of the possibility of AMI following COVID-19 vaccination and potential underlying mechanisms.
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Ou et al. (2023) conducted a case report in Acute myocardial infarction after COVID-19 vaccination (n=1). Inactivated COVID-19 vaccination was evaluated on Acute myocardial infarction. An 83-year-old male developed acute myocardial infarction one day after receiving an inactivated COVID-19 vaccine, potentially due to Type II Kounis syndrome.
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