Key result
Paroxetine linked to reversible QTc prolongation in a single case report.
Case Report (n=1)
Paroxetine may induce reversible QTc prolongation, potentially mediated by HERG channel blockade and autonomic instability.
Suggests QTc monitoring with paroxetine; single case leaves open causality and practice change.
There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HERG) channels. Genetic polymorphisms of channels related to cardiac function are involved in drug-induced QTc prolongation. Moreover, autonomic nervous system instability due to unstable psychotic symptoms may also affect QTc. These factors are related to this rare event induced by paroxetine.
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Yuji Otsuka (2017) conducted a case report in QTc prolongation (n=1). Paroxetine was evaluated on QTc prolongation. A 43-year-old woman developed QTc prolongation (476 ms) after taking 50 mg of paroxetine for 17 days, which normalized to 396 ms three days after discontinuation.
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