Key result
Rotavirus vaccine introduction linked to emerging DS-1-like strains and subsequent ~96% G2P[4] predominance.
Observational (n=1,376)
Yes
The distribution of rotavirus genotypes in Nara Prefecture, Japan, shifted following the introduction of rotavirus vaccination in 2011, with G2P[4] becoming predominant by 2015/2016.
This study was conducted to investigate the distribution of rotavirus genotypes in Nara Prefecture, Japan before and after the introduction of rotavirus vaccination in 2011. Since the 2011/2012 season, DS-1-like G1P[8] strains have been detected in Nara Prefecture, accounting for about half of all strains in the 2014/2015 season. During the 2015/2016 season, no DS-1-like G1P[8] strains were detected; G2P[4] was the predominant genotype.
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Sugimoto et al. (2017) conducted an observational in Acute non-bacterial sporadic gastroenteritis (n=1,376). Rotavirus vaccination introduction vs. Pre-vaccination period was evaluated on Distribution of rotavirus genotypes. After rotavirus vaccine introduction in 2011, DS-1-like G1P[8] strains emerged in Nara Prefecture, accounting for ~50% of strains in 2014-2015, before G2P[4] became predominant (96.1%) in 2015-2016.
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